http://link.springer.com/article/10.1007/s11910-015-0545-1
Abstract
Traumatic brain injury (TBI) leads
to multiple short- and long-term changes in neuronal circuits that
ultimately conclude with an imbalance of cortical excitation and
inhibition. Changes in neurotransmitter concentrations, receptor
populations, and specific cell survival are important contributing
factors. Many of these changes occur gradually, which may explain the
vulnerability of the brain to multiple mild impacts, alterations in
neuroplasticity, and delays in the presentation of posttraumatic
epilepsy. In this review, we provide an overview of normal glutamate and
GABA
homeostasis and describe acute, subacute, and chronic changes that
follow injury. We conclude by highlighting opportunities for therapeutic
interventions in this paradigm.
No comments:
Post a Comment