http://nro.sagepub.com/content/22/1/9?etoc
- 1Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
- 2H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
- 3Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
- Zareen Amtul, Department of Psychiatry, University of Western Ontario, 800 Commissioners Road East, London, Ontario, Canada N6A 5W9. Email: zamtul@uwo.ca
Abstract
Current models of memory storage recognize
posttranslational modification vital for short-term and mRNA
translation for long-lasting
information storage. However, at the molecular
level things are quite vague. A comprehensive review of the molecular
basis
of short and long-lasting synaptic plasticity
literature leads us to propose that the hydrogen bonding pattern at the
molecular
level may be a permissive, vital step of memory
storage. Therefore, we propose that the pattern of hydrogen bonding
network
of biomolecules (glycoproteins and/or DNA template,
for instance) at the synapse is the critical edifying mechanism
essential
for short- and long-term memories. A novel aspect
of this model is that nonrandom impulsive (or unplanned) synaptic
activity
functions as a synchronized positive-feedback
rehearsal mechanism by revising the configurations of the hydrogen
bonding network
by tweaking the earlier tailored hydrogen bonds.
This process may also maintain the elasticity of the related synapses
involved
in memory storage, a characteristic needed for such
networks to alter intricacy and revise endlessly. The primary purpose
of this review is to stimulate the efforts to
elaborate the mechanism of neuronal connectivity both at molecular and
chemical
levels.
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