Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, March 2, 2017

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: A 2-y randomized controlled trial of calorie restriction in nonobese humans

In case you want  to talk to your doctor about calorie restriction diets that might help aging.
I've got 6 posts on caloric restriction with these interesting lines in them; What is your doctors answer to this idea? Would it help your stroke recovery?
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Caloric restriction has been showed to increase levels of a protein in the brain called BDNF. This protein is thought to be involved in the generation of new brain cells, Mattson said.
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Research on animals also suggests caloric restriction reduces neurological damage after a stroke, but only on young or middle-aged animals.
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Massachusetts Institute of Technology (MIT) decided to dig further and ask: Could calorie restriction also delay nerve cell loss in the brain – and the changes in learning and memory that go along with it?
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Calorie restriction of 20 to 30 percent will increase neurogenesis. Intermittent fasting -- spacing the time between your meals -- will increase neurogenesis.
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It’s already well known that a diet may have a life-extending effect. Researchers from Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, Germany, now showed that besides improving the functionality of stem cells in mice, a caloric restriction also leads to a fatale weakening of their immune system

The latest here:

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: A 2-y randomized controlled trial of calorie restriction in nonobese humans

American Journal of Clinical Nutrition, 03/02/2017
This study was performed to assessed the impact of a 2–y calorie restriction (CR) regimen on body composition including the impact of sex and body mass index (BMI; in kg/m2) among participants selected in CALERIE–2 (Comprehensive Assessment of Long–term Effects of Reducing Intake of Energy). It was concluded that 2–years of CR had extensively ideal impacts on both whole–body and regional adiposity that could facilitate healthspan in humans. The decrements in FFM were commensurate with the decreased body mass; in spite of the fact that men in the CR group lost more FFM than the women did, the percentage of FFM in the men in the CR group was higher than at baseline.

Methods

  • For this study they designed a multicenter, randomized controlled trial.
  • A sum of 218 non obese adults participants 21–51 y old (BMI: 21.9–28.0) who were randomly assigned to 25% CR (CR, n = 143) or ad libitum control (AL, n = 75) in a 2:1 ratio.
  • Measures at baseline and 12 and 24 mo included body weight, waist circumference, fat mass (FM), fat–free mass (FFM), and appendicular mass by dual–energy X–ray absorptiometry; activity–related energy expenditure (AREE) by doubly labeled water; and dietary protein consumption by self–report.
  • In this study values are expressed as means ± SDs.

Results

  • They found the CR group achieved 11.9% ± 0.7% CR over 2–y and had significant reductions in weight (–7.6 ± 0.3 compared with 0.4 ± 0.5 kg), waist circumference (–6.2 ± 0.4 compared with 0.9 ± 0.5 cm), FM (–5.4 ± 0.3 compared with 0.5 ± 0.4 kg), and FFM (–2.0 ± 0.2 compared with –0.0 ± 0.2 kg) at 24 mo relative to the AL group (all between–group P < 0.001).
  • Moreover, FFM as a percentage of body weight at 24 mo was higher, and percentage of FM was lower in the CR group than in the AL.
  • AREE, but not protein consumption, predicted preservation of FFM during CR (P < 0.01).
  • Men in the CR group lost significantly more trunk fat (P= 0.03) and FFM expressed as a percentage of weight reduction (P < 0.001) than women in the CR group.
Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report

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