- The authors searched the medical literature to identify cohort studies involving adults with SBI detected by magnetic resonance imaging who were subsequently followed up for incident clinically defined stroke.
- Study data and quality assessment were recorded in duplicate with disagreements in data extraction resolved by a third reader.
- Strength association between magnetic resonance imaging-detected SBI and future symptomatic stroke was measured by an hazard ratio.
- The meta-analysis included 13 studies (14 764 subjects) with a mean follow-up ranging from 25.7 to 174 months.
- SBI predicted the occurrence of stroke with a random effects crude relative risk of 2.94 (95% confidence interval, 2.24-3.86, P<0.001; Q=39.65, P<0.001).
- In the 8 studies of 10 427 subjects providing hazard ratio adjusted for cardiovascular risk factors, SBI was an independent predictor of incident stroke (hazard ratio, 2.08 [95% confidence interval, 1.69-2.56; P<0.001]; Q=8.99; P=0.25).
- In a subgroup analysis pooling 9483 stroke-free individuals from large population-based studies, SBI was present in ≈18% of participants and remained a strong predictor of future stroke (hazard ratio, 2.06 [95% confidence interval, 1.64-2.59]; P<0.01).