Deans' stroke musings: Safety and Efficacy of Remote Ischemic Preconditioning in Patients with Severe Carotid Artery Stenosis Prior to Carotid Artery Stenting: A Proof-of-Concept, Randomized Controlled Trial

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, March 14, 2017

Safety and Efficacy of Remote Ischemic Preconditioning in Patients with Severe Carotid Artery Stenosis Prior to Carotid Artery Stenting: A Proof-of-Concept, Randomized Controlled Trial

I wonder why closing up of the carotid artery is not considered if the Circle of Willis is complete rather than go thru the risks of stenting or endarterectomy.
http://www.docguide.com/safety-and-efficacy-remote-ischemic-preconditioning-patients-severe-carotid-artery-stenosis-prior-ca?
Zhao W, Meng R, Ma C, Hou B, Jiao L, Zhu F, Wu W, Shi J, Duan Y, Zhang R, Zhang J, Sun Y, Zhang H, Ling F, Wang Y, Feng W, Ding Y, Ovbiagele B, Ji X; Circulation (Feb 2017)

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BACKGROUND -Remote ischemic preconditioning (RIPC) can inhibit recurrent ischemic events effectively in patients with acute or chronic cerebral ischemia. However, it is still unclear that whether RIPC can impede ischemic injury after carotid artery stenting (CAS) in patients with severe carotid artery stenosis.
METHODS -Subjects with severe carotid artery stenosis were recruited in this randomized controlled study, and assigned to RIPC, sham and no intervention (control) groups. All subjects received standard medical therapy. Subjects in the RIPC and sham groups underwent RIPC and sham RIPC twice daily respectively for 2 weeks prior to CAS. Plasma NSE and S-100B were used to evaluate safety, hypersensitive C-reactive protein (hs-CRP) and new ischemic DWI lesions were used to determine treatment efficacy. The primary outcomes were the presence of ≥ 1 newly ischemic brain lesions on DWI within 48 hours after stenting and clinical events within 6 months after stenting.
RESULTS -We randomized 189 subjects in this study (63 subjects in each group). Both RIPC and sham RIPC procedures were well tolerated and completed with high compliance (98.41% and 95.24% respectively). Neither plasma NSE levels nor S-100B levels changed significantly before and after treatment. No severe adverse event was attributed to RIPC and sham RIPC procedures. The incidence of new DWI lesions in the RIPC group (15.87%) was significantly lower than the sham group (36.51%; RR 0.44; 96% CI 0.20 to 0.91, p<0.01) and the control group (41.27%; RR 0.39, 96% CI 0.21 to 0.82; p<0.01). The volumes of lesions were smaller in the RIPC group compared to the control and sham groups (p<0.01 each). Ischemic events occurred after CAS were 1 TIA in RIPC group, 2 strokes in control group and two strokes and one TIA in sham group, but these results were not significantly different among three groups (p=0.597).
CONCLUSIONS -RIPC is safe in patients undergoing CAS, which may be able to decrease ischemic brain injury secondary to CAS. However, the mechanisms and effects of RIPC on clinical outcomes in this cohort of patients need further investigation.Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01654666.