Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, March 2, 2017

Vitamin D supplementation improves simvastatin-mediated decline in exercise performance: A randomized, double-blind, placebo-controlled study

Would the same vitamin D supplementation be necessary for stroke survivors taking statins? Ask your doctor. Would this help our fatigue? A fuckingly simple question that will never be answered because we have NO stroke strategy or leadership.
https://www.mdlinx.com/internal-medicine/medical-news-article/2017/03/02/cardiorespiratory-fitness/7072803/?
Journal of Diabetes, 03/02/2017
In the present study, researchers find out the impact of vitamin D supplementation on simvastatin–mediated changes in cardiorespiratory fitness and skeletal muscle mitochondrial content after exercise in adults with type 2 diabetes mellitus (T2DM). The outcome suggests simvastatin tends to cause deterioration in exercise–mediated cardiorespiratory fitness and skeletal muscle mitochondrial content in adults with type 2 diabetes, which is blunted by vitamin D supplementation.

Methods

  • For this study they enrolled 25–50 years old vitamin D deficient T2DM patients.
  • Participants performed moderate intensity aerobic exercise for 3–months and were randomized to receive simvastatin 40 mg per day, simvastatin 40 mg daily and vitamin D 60,000 units once weekly, or vitamin D 60,000 units once weekly.
  • The primary results were cardiorespiratory fitness (peak oxygen consumption) and skeletal muscle mitochondrial content (citrate synthase activity in vastus lateralis muscle).

Results

  • A sum of 28 patients finished the study.
  • Cardiorespiratory fitness reduced by 8.4% (p < 0.05) following 3 months of simvastatin therapy.
  • Vitamin D supplementation blunted the decline in cardiorespiratory fitness to 0.6% (p < 0.05 for between–group difference in change from baseline).
  • Similarly, skeletal muscle mitochondrial content reduced by 3.6% with simvastatin however enhanced by 12.1% on supplementation with vitamin D, although the between– group difference was insignificant.
  • Vitamin D alone expanded cardiorespiratory fitness and mitochondrial content by 7.1% (p < 0.05) and 16.7% respectively.
Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report

1 comment:

  1. FINALLY - research data that proves the fatigue reported by statins users is not a figment of their imagine!

    ReplyDelete