https://www.mdlinx.com/internal-medicine/medical-news-article/2017/03/02/cardiorespiratory-fitness/7072803/?
Journal of Diabetes, 03/02/2017
In
the present study, researchers find out the impact of vitamin D
supplementation on simvastatin–mediated changes in cardiorespiratory
fitness and skeletal muscle mitochondrial content after exercise in
adults with type 2 diabetes mellitus (T2DM). The outcome suggests
simvastatin tends to cause deterioration in exercise–mediated
cardiorespiratory fitness and skeletal muscle mitochondrial content in
adults with type 2 diabetes, which is blunted by vitamin D
supplementation.
Methods
- For this study they enrolled 25–50 years old vitamin D deficient T2DM patients.
- Participants performed moderate intensity aerobic exercise for 3–months and were randomized to receive simvastatin 40 mg per day, simvastatin 40 mg daily and vitamin D 60,000 units once weekly, or vitamin D 60,000 units once weekly.
- The primary results were cardiorespiratory fitness (peak oxygen consumption) and skeletal muscle mitochondrial content (citrate synthase activity in vastus lateralis muscle).
Results
- A sum of 28 patients finished the study.
- Cardiorespiratory fitness reduced by 8.4% (p < 0.05) following 3 months of simvastatin therapy.
- Vitamin D supplementation blunted the decline in cardiorespiratory fitness to 0.6% (p < 0.05 for between–group difference in change from baseline).
- Similarly, skeletal muscle mitochondrial content reduced by 3.6% with simvastatin however enhanced by 12.1% on supplementation with vitamin D, although the between– group difference was insignificant.
- Vitamin D alone expanded cardiorespiratory fitness and mitochondrial content by 7.1% (p < 0.05) and 16.7% respectively.
FINALLY - research data that proves the fatigue reported by statins users is not a figment of their imagine!
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