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Researchers suggest that delivering drugs to the brain using nanoparticles in a nasal spray could be an effective and rapid method capable of overcoming the problem of traversing the blood-brain barrier.
For the brain to function, it must operate in a tightly controlled chemical environment that is protected from the more varied fluctuations of the rest of the body.
This stable environment is maintained by the blood-brain barrier, which comprises layers of specialized cells in the inner linings of the small blood vessels in the brain and spinal cord.
The blood-brain barrier prevents toxins from entering the tissues of the brain and spinal cord. Unfortunately, it does the job so well that it also keeps out many drugs, such as those used to kill cancer cells.
Nose offers easy access to the brainInterest in using nanotechnology - the ability to control matter at the atomic and molecular scale - to develop new diagnostic tools and treatments is growing, note the authors in their study report.
A number of new nanomaterials have been used to carry drugs to specific targets in organs and tissues. These appear to maximize drug effectiveness while minimizing side effects.
Co-author Barani Raman, associate professor of biomedical engineering, says that the nose offers the shortest - and most likely the easiest - route to the brain.
He and his colleagues note that from various studies, gold nanoparticles have emerged as the material of choice for drug delivery. They are relatively easy to synthesize and customize, and they have good biocompatibility.
The team developed a new aerosol diffusion method that deposits gold nanoparticles in the upper regions of the nasal cavity. They produced the nanoparticles to a controlled shape, size, and surface charge, and tagged them with fluorescent markers so that they could track them.
Locusts offer a good model of the human blood-brain barrierThe researchers tested the effectiveness of the nanoparticle aerosol in locusts because their blood-brain barriers bear similarities to those of humans - especially when going through the nasal route.
The team exposed the locusts' antennae to the aerosol and tracked the progress of the tagged nanoparticles. Within a few minutes, the nanoparticles had traversed the insects' olfactory circuitry, passed through the brain-blood barrier, and suffused the brain tissue.
The team showed that the nanoparticles did not affect the insects' brain function. They measured the electrophysiological responses of the locusts' olfactory neurons before and after treatment and found no discernible difference up to several hours afterwards.
The researchers say that the next stage of their research will be to load the nanoparticles with different drugs and use ultrasound to target precise doses to reach specific areas of the brain. Such methods could potentially make a big difference to the treatment of brain tumors.