Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Saturday, April 22, 2017

Microvascular endothelial dysfunction can predict dementia

Is this one of the tests your doctor is doing so that the dementia prevention protocol can be implemented in full force?
https://medicalxpress.com/news/2017-04-microvascular-endothelial-dysfunction-dementia.html

(HealthDay)—Markers of microvascular endothelial dysfunction can predict dementia, according to a study published online April 13 in the Journal of Internal Medicine.
Hilma Holm, from Lund University in Malmö, Sweden, and colleagues examined the longitudinal association of midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal endothelin-1 (CT-proET-1), and midregional pro-adrenomedullin (MR-proADM) with in a population-based cohort of 5,347 individuals without prevalent dementia (age, 69 ± 6 years).
Over a period of 4.6 ± 1.3 years, 373 patients were diagnosed with dementia. The researchers found that there were significant associations for higher levels of MR-proANP with increased risk of all-cause and (hazard ratio per one standard deviation, 1.2 and 1.52, respectively). Across quartiles of MR-proANP, there was an increase in the risk of all-cause dementia (hazard ratio, 1.83 for quartile 4 versus 1), which was most pronounced for vascular type (hazard ratio, 2.71). Vascular dementia was predicted by the two highest quartiles of CT-proET-1, with a cut-off value at 68 pmol/L (hazard ratio, 1.94 for quartiles 3 to 4 versus 1 to 2). After adjustment for traditional risk factors, elevated levels of MR-proADM indicated no increased risk of developing dementia.
"Elevated plasma concentration of MR-proANP is an independent predictor of all-cause and vascular dementia," the authors write. "Pronounced increase in CT-proET-1 indicates higher risk of vascular dementia."
 
More information: Abstract
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Journal reference: Journal of Internal Medicine search and more info website

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