Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Thursday, April 27, 2017

Regenerative Angiogenesis Quality Over Quantity

We need this. What is your doctor doing to create angiogenesis in your brain?
Matthew J. Durand, Karima Ait-Aissa, David D. Gutterman
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Angiogenesis can broadly be defined as the growth of new capillaries and blood vessels. A complex set of multiphasic signaling pathways regulate angiogenic blood vessel growth,1,2 and these pathways have been the target for both pro- and antiangiogenic therapies. Angiogenesis is a fundamental physiological process that is required for fetal development, wound healing, and tissue repair after ischemic damage. For these reasons, promoting proangiogenic pathways has therapeutic potential to combat diseases where tissue blood flow is compromised, such as peripheral artery disease, ischemic heart disease, or after ischemic stroke. Thus, quantitative methods to assess the degree of angiogenic growth are critical.
Article, see p 1453
Typically, blood vessel density and the degree of angiogenic growth are quantified histologically by counting the number of capillaries observed in a defined cross section of tissue. When angiogenesis occurs, the ratio of capillaries per tissue surface area increases. Functional measures of angiogenesis include measuring perfusion to the tissue involved, and it is typically expected that these parameters (vascular density and perfusion) change in parallel. However, this is not always the case.1 In fact, injured tissue may demonstrate both an increase in capillary density and an increase in blood flow but still have underperfused areas. Such a discrepancy could be because of improper vasoregulation of new vessels, or creation of arteriovenous anastomoses that maintain overall tissue flow, …
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