Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Monday, April 24, 2017

Naked Mole-Rats Take on Plant-like Role to Survive Oxygen Deprivation

How do we duplicate this to stop brain cell death in humans due to lack of oxygen? There are so many ways to help stroke survivors and yet no one does fucking anything. Put me in charge and I will make things happen. Will need a few billionaire and millionaire friends to get me started.
http://www.biosciencetechnology.com/news/2017/04/naked-mole-rats-take-plant-role-survive-oxygen-deprivation?
Metabolizing fructose to produce energy anaerobically through a specific metabolic pathway is a process that scientists previously thought was only used by plants.  Not so, says new research.
Naked mole-rats can survive low-oxygen conditions that in all other mammals would normally result in brain cell death, by making a switch from a glucose-based system that depends on oxygen, to one where their brain cells start burning fructose.
“This is just the latest remarkable discovery about the naked mole-rat —a cold-blooded mammal that lives decades longer than other rodents, rarely gets cancer, and doesn’t feel many types of pain,” study leader, Thomas Park, professor of biological sciences at the University of Illinois at Chicago, said in a statement.
For the study, published this week in Science, naked mole-rats were exposed to low oxygen levels in the lab, and researchers observed that large amounts of fructose was released into the bloodstream. Molecular fructose pumps, which are only found on cells of the intestine in all other mammals, transport the fructose into the naked mole-rats brain cells.
Park has studied the interesting creature for 18 years and said: “The naked mole-rat has simply rearranged some basic building-blocks of metabolism to make it super-tolerant to low oxygen conditions.”
The animals go into a state of suspended animation and can even live through 18 minutes of total oxygen deprivation.  When they go into the suspended animation state, their breathing slows dramatically, as well as their heart rate, which drops from 200 to about 50 beats per minute.  They are the only mammals known to employ this method for survival of oxygen deprivation.
Once oxygen becomes available, they resume normal activity with no signs of lasting damage.
Naked mole-rats can survive for at least five hours in low oxygen levels that would kill a human within minutes, Park said.
The animal is also able to avoid deadly pulmonary edema, which is a buildup of fluid in the lungs due to lack of oxygen that often affects high altitude mountain climbers.
Naked mole-rats live underground in densely populated conditions with hundreds of colony mates. The researchers hypothesize that the naked mole-rat may have developed this survival mechanism as an adaptation to its living situation.
Deeper understanding as to how the animals manage this feat could have implications for treating patients experiencing oxygen deprivation such as in heart attacks and strokes.

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