Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Saturday, April 29, 2017

Plaster against blood clots

Might be useful in stenting procedures to stop all the tiny strokes that occur during and after stenting.
A new clinical study is starting at the German Centre for Cardiovascular Research (DZHK) with an innovative and highly specific blood thinner. Headed by the DZHK Munich site, the scientists want to ascertain how safely and effectively this compound, which only acts locally, can prevent blood clots in patients with a coronary heart disease being treated with a cardiac catheter.
The coronary vessels are blocked in coronary heart disease. If physicians dilate the vessels with a catheter, the deposits (plaques) can tear and damage the walls of the blood vessels. Such small damages are a risk factor for circulatory disorders and heart attacks, as platelets can adhere to these sites and clots can form. Patients therefore receive blood thinning drugs that prevent platelet accumulation during the procedure. The disadvantage of the drugs used to date is that they also increase the risk of potentially life‑threatening bleedings, because they inhibit a central step of haemostasis, or platelet accumulation, in the entire body. The purpose of the DZHK study, which is headed by the German Heart Centre Munich, is to investigate whether the new antiplatelet drug Revacept reduces the formation of blood clots during cardiac catheterisation without increasing the bleeding risk. In comparison to conventional blood thinners, Revacept only binds to the damaged sites in the vessel and shields them so that no platelets can accumulate there. “Revacept is like a plaster that seals the lesion in a targeted manner”, exemplifies PD Dr. Stefanie Schüpke of the German Heart Centre Munich.

From the laboratory to the patient

Years of intensive basic research, in which scientists at LMU Munich and the Technical University Munich researched how platelets adhere to damaged vessel sites, preceded the development of Revacept. “It was crucial to target structures that distinguish between healthy and atherosclerotic vessels”, explains Prof. Adnan Kastrati of the German Heart Centre Munich, one of the chief investigators. For this reason, the scientists focused on the adhesion of platelets to the collagen that only protrudes into the blood stream where vessel walls are damaged. The agent Revacept was created based on their findings. It binds to the collagen of the damaged sites in a targeted manner and thus prevents the adhesion of platelets. “Revacept is an example of successful translational research, in which the findings from basic research lead to the development of innovative therapies”, clarifies Prof. Thomas Eschenhagen, the representative of the DZHK Board of Directors.

For the first time in patients with coronary heart disease

Revacept was further developed into a drug for use in humans by the biotech company advanceCOR, a spin-off of the Technical University Munich. A previous study with healthy volunteers has already proven that Revacept is safe and well tolerated. Moreover, a clinical trial is already being conducted investigating Revacept in stroke patients. In the upcoming study, 332 patients with a coronary heart disease for whom a catheterisation is planned will be examined. Some patients will be treated with Revacept in addition to the usual medication. During the study, bleeding risk will be monitored and a marker in the blood will be used to investigate whether Revacept sufficiently prevents damage of the heart muscle. In total, six DZHK sites are participating in the study, which is co-financed by the manufacturer, advanceCOR GmbH in Martinsried.

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