Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, April 27, 2017

Study Shows Parkinson’s Disease May Start in the Gut

Rather than cutting the vagus nerve we should be figuring out a less invasive way to stop the signals or whatever travels along the vagus nerve. In our case stimulating the vagus nerve seems to help stroke recovery. So ask your doctor on the pros and cons of stroke recovery vs. Parkinsons prevention.

The positive:

Nerve 'Zap' Treatment May Speed Stroke Recovery Mar. 2017 

Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke  Jan. 2016 

Earlier research on this is here July, 2012;

Nerve stimulation plus standard therapy may accelerate stroke recovery

and here Jan. 2013;

UK docs aim to `rewire` brains of stroke patients

and here - Sept. 2013;

Researchers Find Early Success in New Treatment for Stroke Recovery

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The negative:

Vagus Nerve Stimulation Falls Short in Stroke Rehabilitation  Mar. 2017 

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Study Shows Parkinson’s Disease May Start in the Gut

April 26, 2017
MINNEAPOLIS, Minn -- April 26, 2017 -- Parkinson’s disease may start in the gut and spread to the brain via the vagus nerve, according to a study published in the April 26, 2017, online issue of Neurology.
The preliminary study examined people who had resection surgery, removing the main trunk or branches of the vagus nerve. The researchers used national registers in Sweden to compare 9,430 people who had a vagotomy over a 40-year period with 377,200 people from the general population.
During that time, 101 people who had a vagotomy developed Parkinson’s disease (1.07%), compared with 4,829 people in the control group (1.28%). This difference was not statistically significant.
However, when researchers analysed the results for the 2 different types of vagotomy surgery, they found that people who had a truncal vagotomy at least 5 years earlier were less likely to develop Parkinson’s disease than those who had not had the surgery and had been followed for at least 5 years.
A total of 19 people who had truncal vagotomy at least 5 years earlier developed the disease (0.78%), compared with 932 people who had no surgery and had been followed for at least 5 years (1.15%). By contrast, 60% of patients who had selective vagotomy 5 years earlier developed Parkinson’s disease (1.08%).
After adjusting for factors such as chronic obstructive pulmonary disease, diabetes, arthritis, and other conditions, the researchers found that people who had a truncal vagotomy at least 5 years before were 40% less likely to develop Parkinson’s disease than those who had not had the surgery and had been followed for at least 5 years.
“These results provide preliminary evidence that Parkinson’s disease may start in the gut,” said Bojing Liu, Karolinska Instituet, Stockholm, Sweden. “Other evidence for this hypothesis is that people with Parkinson’s disease often have gastrointestinal problems, such as constipation, that can start decades before they develop the disease. In addition, other studies have shown that people who will later develop Parkinson’s disease have a protein believed to play a key role in Parkinson’s disease in their gut.”
The theory is that these proteins can fold in the wrong way and spread that mistake from cell to cell.
“Much more research is needed to test this theory and to help us understand the role this may play in the development of Parkinson’s,” Liu said.
Additionally, since Parkinson’s is a syndrome, there may be multiple causes and pathways.
Even though the study was large, Liu said one limitation was small numbers in certain subgroups. Also, the researchers could not control for all potential factors that could affect the risk of Parkinson’s disease, such as smoking, coffee drinking or genetics.
SOURCE: American Academy of Neurology

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