Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, April 20, 2017

Scientists hope they have found a drug to stop all neurodegenerative brain diseases, including dementia

With a great stroke association we could join these researchers in finding a feasible solution. But that will never occur until we destroy the existing fucking failures of stroke associations. NO LEADERSHIP AND NO STRATEGY from them.
You need this solution and soon.
1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research.   July 2013.

Scientists hope they have found a drug to stop all neurodegenerative brain diseases, including dementia

In 2013, a UK Medical Research Council team stopped brain cells dying in an animal for the first time, creating headline news around the world.
But the compound used was unsuitable for people, as it caused organ damage.
Now two drugs have been found that should have the same protective effect on the brain and are already safely used in people.
"It's really exciting," said Prof Giovanna Mallucci, from the MRC Toxicology Unit in Leicester.
She wants to start human clinical trials on dementia patients soon and expects to know whether the drugs work within two to three years.

Why might they work?

The novel approach is focused on the natural defence mechanisms built into brain cells.
When a virus hijacks a brain cell it leads to a build-up of viral proteins.
Cells respond by shutting down nearly all protein production in order to halt the virus's spread.
Many neurodegenerative diseases involve the production of faulty proteins that activate the same defences, but with more severe consequences.
The brain cells shut down production for so long that they eventually starve themselves to death.
This process, repeated in neurons throughout the brain, can destroy movement, memory or even kill, depending on the disease.
It is thought to take place in many forms of neurodegeneration, so safely disrupting it could treat a wide range of diseases.
In the initial study, the researchers used a compound that prevented the defence mechanism kicking in.
It halted the progress of prion disease in mice - the first time any neurodegenerative disease had been halted in any animal.
Further studies showed the approach could halt a range of degenerative diseases.
The findings were described as a "turning point" for the field even though the compound was toxic to the pancreas.

Neurodegeneration

  • A neurodegenerative disease is one in which the cells of the brain and spinal cord are lost
  • The functions of these cells include decision making and control of movements
  • These cells are not easily regenerated, so the effects of diseases can be devastating
  • Neurodegenerative diseases include Alzheimer's, Parkinson's, multiple sclerosis and Huntington's
Source: London Brain Centre

Safe drugs?

Since 2013, the research group has tested more than 1,000 ready-made drugs on nematode worms, human cells in a dish and mice.
Two were shown to prevent both a form of dementia and prion disease by stopping brain cells dying.
Prof Mallucci told the BBC News website: "Both were very highly protective and prevented memory deficits, paralysis and dysfunction of brain cells."
The best known drug of the pair is trazodone, which is already taken by patients with depression.
The other, DBM, is being tested in cancer patients.
Prof Mallucci said: "It's time for clinical trials to see if there's similar effects in people and put our money where our mouth is.
"We're very unlikely to cure them completely, but if you arrest the progression you change Alzheimer's disease into something completely different so it becomes liveable with."
But, although trazodone is a current medication, she added: "As a professional, a doctor and a scientists, I must advise people to wait for the results."

What do the experts think?

Dr Doug Brown, from the Alzheimer's Society, said: "We're excited by the potential of these findings, from this well conducted and robust study.
"As one of the drugs is already available as a treatment for depression, the time taken to get from the lab to the pharmacy could be dramatically reduced."
Dr David Dexter, from Parkinson's UK, said: "This is a very robust and important study.
"If these studies were replicated in human clinical trials, both trazodone and DBM could represent a major step forward."

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