Deans' stroke musings: Drug Caused Arterial Plaque in Mice to 'Melt Away' (CNBC)

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, November 12, 2017

Drug Caused Arterial Plaque in Mice to 'Melt Away' (CNBC)

You'll have to wait decades before any followup is done. It mentions coronary not cerebral so our stroke medical professionals will never put two and two together and decide this might help prevent stroke also.
https://www.medpagetoday.com/cardiology/atherosclerosis/69027

Regression observed after initial dos

by MedPage Today Staff November 03, 2017

Atherosclerotic plaque in mice began to "melt away" after a single dose of the investigational drug trodusquemine, CNBC reported.
Researchers at the University of Aberdeen in Scotland studied mice that had established coronary atherosclerosis. The animals received either trodusquemine or standard treatment, and the amount of atherosclerotic plaque was measured before and after treatment. Plaque regressed significantly after the initial dose of trodusquemine, a protein tyrosine phosphatase 1B inhibitor also evaluated as a treatment for cancer and diabetes.

"These have only been tested at the preclinical level, in mice, so far, but the results were quite impressive and showed that just a single dose of this drug seemed to completely reverse the effects of atherosclerosis," said principal investigators Mirela Delibegovic, PhD, adding that investigators plan to test the drug in humans.