Is anyone ever going to put together a protocol on using tDCS and which type? Otherwise all this fucking research and reviews are totally worthless. This is why we need strong stroke leadership, to actually help stroke survivors.
HD-tDCS (3)
cathodal tDCS (6)
anodal tDCS (9)
tDCS (61)
Neuroplasticity and network connectivity of the motor cortex following stroke: A transcranial direct current stimulation study
First published:
14 April 2018
https://doi.org/10.1002/hbm.24079
Funding information National Health and Medical Research Council (NHMRC), Grant/Award N ... More
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Abstract
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation
technique that has potential for clinical utility in neurorehabilitation. However,
recent evidence indicates that the responses to tDCS are highly variable. This study
investigated whether electroencephalographic (EEG) measures of functional connectivity
of the target network were associated with the response to ipsilesional anodal tDCS
in stroke survivors. Ten chronic stroke patients attended two experimental sessions
in a randomized cross‐over trial and received anodal or sham tDCS. Single‐pulse transcranial
magnetic stimulation was used to quantify change in corticospinal excitability following
tDCS. At the beginning of each session, functional connectivity was estimated using
the debiased‐weighted phase lag index from EEG recordings at rest. Magnetic resonance
imaging identified lesion location and lesion volume. Partial least squares regression
identified models of connectivity which maximally accounted for variance in anodal
tDCS responses. Stronger connectivity of a network with a seed approximating the stimulated
ipsilesional motor cortex, and clusters of electrodes approximating the ipsilesional
parietal cortex and contralesional frontotemporal cortex in the alpha band (8–13 Hz)
was strongly associated with a greater increase of corticospinal excitability following
anodal tDCS. This association was not observed following sham stimulation. Addition
of a structural measure(s) of injury (lesion volume) provided an improved model fit
for connectivity between the seed electrode and ipsilesional parietal cortex, but
not the contralesional frontotemporal cortex. TDCS has potential to greatly assist
stroke rehabilitation and functional connectivity appears a robust and specific biomarker
of response which may assist clinical translation of this therapy.
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