But nothing will occur because they can't add 1+1.
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2006.04122.x
Address correspondence and reprint requests to Dr Laura M. Frago, Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo 65, 28009 Madrid, Spain
E‐mail: laura.frago@uam.es
Abstract
Chronic systemic treatment given to adult male rats with growth hormone releasing
peptide‐6, an agonist of the ghrelin receptor, increases insulin‐like growth factor
I levels in various brain regions, including the hypothalamus and cerebellum. Furthermore,
intracellular signalling cascades normally associated with anti‐apoptotic actions
are activated in the same areas and are coincident with decreased basal cell death.
Because abnormally high concentrations of glutamate can lead to overexcitation of
neurones leading to cell damage and/or death, we investigated whether administration
of growth hormone releasing peptide‐6 attenuates monosodium glutamate‐induced apoptosis
in the rat hypothalamus and cerebellum. Glutamate increased activation of caspase
9 followed by cleavage of caspase 7, which in turn fragmented poly(ADP‐ribose) polymerase,
terminating in cell death in both the hypothalamus and cerebellum. Growth hormone
releasing peptide‐6 reversed glutamate‐induced cell death by decreasing activation
of caspases 9 and 7 and poly(ADP‐ribose) polymerase fragmentation. These results provide
a better understanding of the neuroprotective role of growth hormone secretagogues
and the mechanisms involved.
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