Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, June 26, 2018

Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia

Does your doctor even know what normobaric oxygen is? Or is s/he waiting for  SOMEONE ELSE TO SOLVE THE PROBLEM and deliver a protocol? 
How fucking hard is it to deliver oxygen to stroke patients? Or aren't you willing to take the chance on translating this research from rats to humans?  

There is this from March, 2005:

A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke

 And this in October, 2010

Normobaric oxygen therapy in acute ischemic stroke: A pilot study in Indian patients

And this from October 2012:

Normobaric Oxygen Therapy

HOW FUCKING LONG WILL YOU LET YOUR INCOMPETENT STROKE HOSPITAL STILL TREAT PATIENTS LIKE NOTHING NEW HAS OCCURRED IN THE PAST 50 YEARS?



Different Effects of Normobaric Oxygen in Normotensive Versus Hypertensive Rats After Focal Cerebral Ischemia

Jing Lan, Elga Esposito, Cenk Ayata, Aneesh B. Singhal, Eng H. Lo, Xunming Ji
https://doi.org/10.1161/STROKEAHA.118.020626
Stroke. 2018;49:1534-1537
Originally published April 30, 2018

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Visual Overview

Figure1

Abstract

Background and Purpose—The efficacy of neuroprotective approaches in stroke may be influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia (NBO) in normotensive versus hypertensive rats subjected to transient focal cerebral ischemia.
Methods—Male Sprague–Dawley and spontaneously hypertensive rats were subjected to transient focal ischemia via intraluminal filament occlusions of the middle cerebral artery. NBO was started 15 minutes after ischemic onset and stopped at the time of reperfusion. Acute neurological deficits and tetrazolium-stained infarct volumes were quantified at 24 hours.
P=0.0064) in normotensive Sprague–Dawley rats subjected to 100 minutes transient ischemia. No effects of NBO were observed in hypertensive spontaneously hypertensive rats subjected to either 100 minutes or 75 minutes of transient ischemia. No significant changes in neurological outcomes were detectable in any group.
Conclusions—NBO reduced infarction in Sprague–Dawley but not in spontaneously hypertensive rats. These findings suggest that comorbidities may influence responses to potential treatments after stroke.
  • Received January 19, 2018.
  • Revision received March 16, 2018.
  • Accepted March 22, 2018.
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