Ask your doctor; What is the path forward to 100% recovery?
Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon
Neurorehabilitation and Recovery (J Krakauer and T Kitago, Section Editors)
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Part of the following topical collections:
Abstract
Purpose of Review
Studies
in humans and animal models show that most recovery from impairment
occurs in the first 1–3 months after stroke as a result of both
spontaneous recovery as well as increased responsiveness to enriched
environments and training. Improvement from impairment is attributable
to a short-lived “sensitive period” of post-stroke plasticity defined by
unique genetic, physiological, and structural events. Unfortunately,
rehabilitative interventions in humans have not been able to exploit
this sensitive period similar to that seen in animal models. Here, we
review these data and suggest a path forward.
Recent Findings
Pre-clinical
data reveal underlying mechanisms that define the post-stroke sensitive
period. These data are then discussed in the context of the spontaneous
post-stroke recovery described in humans.
Summary
Future
work will need to capitalize on unique interactions between the
sensitive period, spontaneous recovery, and novel types of
rehabilitative interventions.
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