So EXACTLY how do you know which subgroup you are in so you can step up your dementia prevention protocols?
Mild cognitive impairment that does not progress to dementia: A population-based study
Journal of the American Geriatrics Society — Ganguli M, et al. | February 13, 2019
In population studies, mild
cognitive impairment (MCI) does not usually progress to dementia in the
short term, but rather stabilizes as MCI or returns to normal cognition,
so researchers described MCI subgroups with various outcomes over 5
years. They defined MCI as Clinical Dementia Rating (CDR) = 0.5 and
dementia as CDR≥1. In a population-based cohort (N=1,603), three MCI
subgroups (progressed to dementia [n=86], stabilized at MCI [n=384], or
reverted to normal [n=252]), were compared to those who remained
consistently normal (n=881). Compared to the normal group, patients in
the MCI groups displayed worse subjective cognitive concerns, functional
impairments, self-rated health, and depressive symptoms. The stable MCI
and reverted to normal groups had more prescription medications.
Diabetes and low diastolic blood pressure were associated with stable
MCI. Stable and progressive MCI were noted in correlation with the APOE4 genotype.
Stroke was noted to be linked with progressive MCI. These findings
suggest different underlying causes. The progressors, unlike the
reverters, displayed a profile largely characteristic of Alzheimer's
disease.
Read the full article on Journal of the American Geriatrics Society
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