Recognising and managing depression is an important part of
post-stroke treatment, but some treatments should be used with caution
until more is known about the risks, according to new evidence published
in the
Cochrane Library today.
The
George Institute for Global Health researchers analyzed the results of
49 trials involving over 3,000 people with depression following a
stroke
and found that while psychological therapy or medication could be
useful, the latter may come with some potentially harmful side effects.
Senior author Professor Maree Hackett, Program Head, Mental Health at
The George Institute said that while depression is an important
consequence of stroke that impacts on recovery, it is often not detected
or is inadequately treated.
"Management of people who have experienced a stroke tends to focus on
the physical effects of the stroke and the psychological effects may be
overlooked. Having depression after stroke can hamper recovery by
reducing a person's motivation or making them unable to keep up with the
recommended rehabilitation," she said.
"People with depression may feel very alone and stop talking to
family and friends, and also may stop taking the medications they have
been given to prevent another stroke."
"That's why it's important to alleviate depression, but our review on
the best way to do this hadn't been updated for over ten years,
(And in those 10 years you haven't moved an inch closer to 100% recovery.) during
which time new trials have been published and different combinations of
treatments have been used," Prof Hackett added.
Cochrane publishes systematic reviews, which summarize all of the
available research evidence, that are used to inform treatment
guidelines.
Lead author of the review and Research Fellow at The George, Dr.
Sabine Allida, said the team had set out to determine which treatments
or combinations of treatments would be most effective at treating
depression and reducing
depressive symptoms after a stroke, based on the best available evidence.
(The best treatment is so fucking obvious. EXACT DEFINED STROKE PROTOCOLS LEADING TO 100% RECOVERY. Knowing what is needed would alleviate the anxiety and depression that comes from not knowing what is ahead.)
"We found a small benefit of antidepressants and talking therapies
(like cognitive behavioral therapy) in treating depression. Studies of
repetitive Transcranial Magnetic Stimulation (rTMS—a mild form of brain
stimulation applied through the scalp and skull) and combined
antidepressant and talking therapy, or antidepressant and rTMS
interventions reduced the number and severity of depressive symptoms
people experienced," she said.
"Our results suggested an increase in side effects for antidepressant
medications such as confusion, sedation and gastrointestinal problems.
Also, the individual trials often included only a small number of
people—we are generally more confident of results when trials include a
lot of people and are well conducted. So more research is need before
recommendations can be made about the routine use of such treatments,"
she added.
While some mood changes can be caused by the effects of a stroke on
the brain, they can also be a reaction to a life changing event and
later on, the realization that there may be things a person is no longer
able to do.
Stroke Foundation Chief Executive Officer Sharon McGowan said that as
many as one in three people experience depression at some point during
the five years after their stroke.
"It's important to recognize that depression and anxiety are common
after a stroke, but they are also treatable. Recovery is possible and
there are many things that can help. The sooner you get help, the sooner
you will move towards recovery," she said.
"It is great to get updated Cochrane reviews that we can now rapidly
integrate into our world-first "Living' Stroke guidelines which
healthcare professionals refer to when caring for people with stroke,"
Ms McGowan added.
Prof Hackett said that future research needs to include a broader
group of people with stroke to be able to draw more definite conclusions
about the most effective treatments.
"In the meantime there are many options to manage
depression
and depressive symptoms—not just antidepressants. Speak with your GP or
neurologist about what is the best option for you, how long you should
be on treatment, and how you/they will know when to stop treatment,"
Prof Hackett added.
More information:
Sabine Allida et al. Pharmacological, psychological, and
non-invasive brain stimulation interventions for treating depression
after stroke,
Cochrane Database of Systematic Reviews (2020).
DOI: 10.1002/14651858.CD003437.pub4
Provided by
George Institute for Global Health