Deans' stroke musings: Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, January 20, 2020

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

I found absolutely nothing in this abstract that even minutely hinted at something useful.

Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration

Rahman MA¹, Rahman MR², Zaman T², Uddin MS³, Islam R⁴, Abdel-Daim MM⁵, Rhim H¹.

Author information

Abstract

BACKGROUND:

Naturally-occurring products derived from living organisms have been shown to modulate various pharmacological and biological activities. Natural products protect against various diseases, which could be used for therapeutic assistance. Autophagy, a lysosome-mediated self-digestion pathway, has been implicated in a range of pathophysiological conditions, and has recently gained attention for its role in several neurodegenerative diseases.

METHODS:

In this current review, we emphasized the recent progress made on our understanding of the molecular mechanism of autophagy in different cellular and mouse models using naturally-occurring autophagy modulators for the management of several neurodegenerative diseases.

RESULTS:

Accumulating evidence has revealed that a wide variety of natural compounds such as alkaloids, polyphenols, terpenoids, xanthonoids, flavonoids, lignans, disaccharides, glycolipoproteins, and saponins(Why not just add every word ending in 'oid' or 'ide' ?) are involved in the modulation of the autophagy signaling pathway. These natural products(arsenic, asbestos, and mercury are natural.) and have been used to treat various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, spinocerebellar ataxia, neuroblastoma, and glioblastoma. Although a number of synthetic autophagy regulators have been recognized as encouraging neurodegenerative therapeutic candidates, natural autophagy-regulating compounds have been of further interest as potential disease therapeutics, as they cause insignificant side effects.

CONCLUSION:

Existing in vitro and in vivo data are promising, and highlight that naturally-occurring autophagy-regulating compounds play an important role for the prevention and treatment of neurodegenerative disorders.