Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury

It is only two pages so your doctor can see if this needs to be added as an immediate intervention post stroke.

Did your doctor do ONE DAMN THING with this earlier research on chondroitin sulfate proteoglycans? So over 5 years of incompetency.

Traffic lights for axon growth: proteoglycans and their neuronal receptors

March 2014

Investigation of Sox9 ablation on neuroplasticity and recovery after ishcemic stroke

September 2014

 

Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury

Corresponding Author Surajit Ghosh − Indian Institute of Technology Jodhpur, Karwar, India; orcid.org/0000-0002-8203-8613; Phone: +91-291-280-1212; Email: sghosh@iitj.ac.in Other Authors Nabanita Mukherjee − Indian Institute of Technology Jodhpur, Karwar, India Subhadra Nandi − Indian Institute of Technology Jodhpur, Karwar, India Shubham Garg − Indian Institute of Technology Jodhpur, Karwar, India Satyajit Ghosh − Indian Institute of Technology Jodhpur, Karwar, India Surojit Ghosh − Indian Institute of Technology Jodhpur, Karwar, India Ramkamal Samat − Indian Institute of Technology Jodhpur, Karwar, India Complete contact information is available at: https://pubs.acs.org/10.1021/acschemneuro.0c00004

Cite This: https://dx.doi.org/10.1021/acschemneuro.0c00004

ABSTRACT: 

Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar formed after severe traumatic brain injury as well as spinal cord injury and play a crucial inhibitory role in axonal regeneration by selective contraction of filopodia of the growth cone of sprouting neurites. Healing of central nervous system (CNS) injury requires degradation of the glycosamine glycan backbone of CSPGs in order to reduce the inhibitory effect of the CSPG layer. The key focus of this Viewpoint is to address a few important regenerative approaches useful for overcoming the inhibitory barrier caused by chondroitin sulfate proteoglycans. KEYWORDS: Central nervous system injury, axonal regeneration, glial scar, chondroitin sulfate proteoglycan, heparan sulfate proteoglycan, chondroitinase ABC enzyme