Would wearing blue light googles immediately upon entering the ambulance or hospital prevent some of the reperfusion injury? We'll never know because we have NO leadership and NO strategy in stroke.
Blue light reduces organ injury from ischemia and reperfusion
Significance
It
is well established that light regulates mammalian biology. And yet, we
have been unable to define and thus harness the underlying mechanisms
so as to apply them to alter the course of human disease. In this study
we determine that the spectrum of light is a critical determinant of its
effect on critical illness. We show that an acute and short (24 h)
exposure to high-illuminance (1,400 lx) blue spectrum (peak 442 nm)
light prior to ischemia/reperfusion (I/R) significantly attenuates the
degree of organ injury. Our characterization of the biological
mechanisms through which blue light beneficially alters the cellular
response to I/R provides an opportunity to develop novel therapeutics
for the prevention and treatment of many diseases.
Keywords: blue light, ischemia, reperfusion, organ injury, circadian rhythms
Abstract
Evidence
suggests that light and circadian rhythms profoundly influence the
physiologic capacity with which an organism responds to stress. However,
the ramifications of light spectrum on the course of critical illness
remain to be determined. Here, we show that acute exposure to bright
blue spectrum light reduces organ injury by comparison with bright red
spectrum or ambient white fluorescent light in two murine models of
sterile insult: warm liver ischemia/reperfusion (I/R) and unilateral
renal I/R. Exposure to bright blue light before I/R reduced
hepatocellular injury and necrosis and reduced acute kidney injury and
necrosis. In both models, blue light reduced neutrophil influx, as
evidenced by reduced myeloperoxidase (MPO) within each organ, and
reduced the release of high-mobility group box 1 (HMGB1), a neutrophil
chemotactant and key mediator in the pathogenesis of I/R injury. The
protective mechanism appeared to involve an optic pathway and was
mediated, in part, by a sympathetic (β3 adrenergic) pathway
that functioned independent of significant alterations in melatonin or
corticosterone concentrations to regulate neutrophil recruitment. These
data suggest that modifying the spectrum of light may offer therapeutic
utility in sterile forms of cellular injury.
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