Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, January 29, 2020

Alzheimer’s disease may be combated by improving blood vessel health in the brain

If there was anything useful in here that I could take to my doctor I couldn't find it.  And what is visually evoked vascular responses?

Alzheimer’s disease may be combated by improving blood vessel health in the brain


A build-up of amyloid-beta in the brain is, by theory, a possible cause of Alzheimer’s disease among older adults. In a recent study, a team of researchers determined how such accumulation could be prevented and even treated.
According to the study, published in the peer-reviewed journal Neuron, improving blood vessel health in the brain may be a new route for combating the neurodegenerative disease.
The study focused on vasomotion, slow vessel pulsations associated with the clearance of substances from the brain, possibly affecting the accumulation of amyloid-beta. Such protein fragments are considered a hallmark sign for Alzheimer’s disease, based on countless studies targeting neurodegeneration.
For the study, researchers administered to rodents dextran, a fluorescently labeled carbohydrate, initiating imaging tests thereafter.
Upon evaluating the findings, researchers quickly noticed something aberrant: Vasomotion was detrimental in clearing dextran from the brain. Also, vessel pulsations were inhibited and clearance rates abated in rodents with cerebral amyloid angiopathy.
“Vasomotion correlated with paravascular clearance of fluorescent dextran from the interstitial fluid,” Susanne van Veluw, co-author of the study, explained.
“Increasing the amplitude of vasomotion by means of visually evoked vascular responses resulted in increased clearance rates in the visual cortex of awake mice. Evoked vascular reactivity was impaired in mice with CAA, which corresponded to slower clearance rates.”
Overall, the findings bring new light on how maintaining healthy vasculature may be beneficial for patients with Alzheimer’s disease.
“Our findings highlight the importance of the vasculature in the pathophysiology of Alzheimer’s disease.”
“If we direct therapeutic strategies towards promoting healthy vasculature and therefore improve clearance of amyloid-beta from the brain, we may be able to prevent or delay the onset of Alzheimer’s disease in the future.”

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