This sentence in the full research is important.
undergone preliminary clinical trials and has provided promising results in
a variety of disease models, including stroke, autoimmune arthritis
Meaning your doctors and stroke hospitals should IMMEDIATELY be contacting researchers to get followup human research done with protocols created. If not, then they need to be fired, starting with the board of directors.
Triphenylphosphonium (TPP)‐Based Antioxidants: A New Perspective on Antioxidant Design
First published: 05 February 2020
Abstract
Mitochondrial oxidative damage and dysfunction contribute to
a wide range of human diseases. Considering the limitation of
conventional antioxidants and that mitochondria are the main source of
reactive oxygen species (ROS) which induce oxidative damage,
mitochondria‐targeted antioxidants which can selectively block
mitochondrial oxidative damage and prevent various types of cell death
have been widely developed. As a lipophilication, triphenylphosphonium
(TPP) has been commonly used in designing mitochondria‐targeted
antioxidants. Conjugated with the TPP moiety, antioxidants can achieve
more than 1000‐fold higher mitochondrial concentration depending on cell
membrane potentials and mitochondrial membrane potentials. Herein we
discuss the deficiencies of conventional antioxidants and the advantages
of mitochondrial targeting, and review various types of TPP‐based
mitochondria‐targeted antioxidants. These provide theoretical and
background support for the design of new anti‐oxidant.
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