Deans' stroke musings: Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, January 24, 2021

Age-related normative changes in cerebral perfusion: Data from The Irish Longitudinal Study on Ageing (TILDA)

You just might want to know your cerebral blood flow compared to normal. If not normal then your doctor needs to initiate protocols to bring it into range.

https://doi.org/10.1016/j.neuroimage.2021.117741 Get rights and content

Under a Creative Commons license

open access

Highlights

•: Normative values presented for cerebral blood flow measured using 3T pCASL-MRI.
•: Data from 468 community-dwelling adults aged 54–84 years.
•: Cerebral blood flow decreased by 0.2 ml/100 g/min for each year increase in age.
•: Cerebral blood flow was 3.1 ml/100 g/min higher in females.

Abstract

Objective

To establish normative reference values for total grey matter cerebral blood flow (CBF_GM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older.

Background

Quantitative assessment of CBF_GM may provide an imaging biomarker for the early detection of those at risk of neurodegenerative diseases, such as Alzheimer's and dementia. However, the use of this method to differentiate normal age-related decline in CBF_GM from pathological reduction has been hampered by the lack of reference values for cerebral perfusion.

Methods

The study cohort comprised a subset of wave 3 (2014–2015) participants from The Irish Longitudinal Study on Ageing (TILDA), a large-scale prospective cohort study of individuals aged 50 and over. Of 4309 participants attending for health centre assessment, 578 individuals returned for 3T multi-parametric MRI brain examinations. In total, CBF_GM data acquired from 468 subjects using pCASL-MRI were included in this analysis. Normative values were estimated using Generalised Additive Models for Location Shape and Scale (GAMLSS) and are presented as percentiles, means and standard deviations.

Results

The mean age of the cohort was 68.2 ± 6.9 years and 51.7% were female. Mean CBF_GM for the cohort was 36.5 ± 8.2 ml/100 g/min. CBF_GM decreased by 0.2 ml/100 g/min for each year increase in age (95% CI = −0.3, −0.1; p ≤ 0.001) and was 3.1 ml/100 g/min higher in females (95% CI = 1.6, 4.5; p ≤ 0.001).

Conclusions

This study is by far the largest single-site study focused on an elderly community-dwelling cohort to present normative reference values for CBF_GM measured at 3T using pCASL-MRI. Significant age- and sex-related differences exist in CBF_GM.