Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, January 31, 2021

Semaphorins in stroke

 Your doctor should know of all of these and have a protocol to utilize them. No knowledge they need to be fired.  We have to clean out a lot of dead wood in stroke. You can see from the dates here that this has been around for a while. There is ABSOLUTELY NO EXCUSE  that our fucking failures of stroke associations haven't put together a protocol on this and distributed it to all stroke doctors and survivors.

Semaphorins and their Signaling Mechanisms January 2018

From there: 

Early studies revealed that semaphorins function as axon guidance molecules,(We need this to have our white matter do the connections needed.) but it is now understood that semaphorins are key regulators of morphology and motility in many different cell types including those that make up the nervous, cardiovascular, immune, endocrine, hepatic, renal, reproductive, respiratory and musculoskeletal systems, as well as in cancer cells.

 

Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D2 Synthase September 2018

 

Following experimental stroke, the recovering brain is vulnerable to lipoxygenase‐dependent semaphorin signaling  October 2012

Serum semaphorin 7A is associated with the risk of acute atherothrombotic stroke  February 2019

Use of semaphorin-4D binding molecules to promote neurogenesis following stroke  May 2012

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A  June 2011

Sustained up-regulation of semaphorin 3A, Neuropilin1, and doublecortin expression in ischemic mouse brain during long-term recovery  February 2008

 

Cellular and molecular mechanisms of neural repair after stroke: making waves April 2006

 

 

 

 

 

 

 

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