Deans' stroke musings: Targeting the Immune System for Ischemic Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 2, 2021

Targeting the Immune System for Ischemic Stroke

They highlight something, but provide NOTHING ON GETTING TO 100% RECOVERY. USELESS.

Targeting the Immune System for Ischemic Stroke

Published:December 16, 2020DOI:https://doi.org/10.1016/j.tips.2020.11.010

Highlights

Stroke is the leading cause of death and disability globally. Two-thirds of stroke survivors are left disabled, requiring assistance in daily living tasks.
Currently, treatments for ischemic stroke are limited to clot lysis and/or mechanical removal within a few hours of stroke onset.
In addition to the brain injury and cell death that occurs rapidly due to severe cerebral ischemia, a secondary phase of infarct growth is driven by inflammation for several days.(Use the correct term:neuronal cascade of death)
There are complex contributions from the innate and adaptive immune systems, but an improved understanding of this process may yield new therapeutic targets to limit stroke injury.

Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke still limited to clot lysis and/or mechanical removal, new therapeutic targets are desperately needed. In this review, we provide an overview of the complex mechanisms of innate and adaptive immune cell-mediated inflammatory injury, that exacerbates infarct development for several days after stroke. We also highlight the features of poststroke systemic immunodepression that commonly leads to infections and some mortalities, and argue that safe and effective therapies will need to balance pro- and anti-inflammatory mechanisms in a time-sensitive manner, to maximize the likelihood of an improved long-term outcome.