I guess you'll have to have your doctor get this and see if it can be used in your recovery.
Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering
Ralf P. Friedrich *, Iwona Cicha and Christoph Alexiou
Citation: Friedrich, R.P.; Cicha, I.;
Alexiou, C. Iron Oxide Nanoparticles
in Regenerative Medicine and Tissue
Engineering. Nanomaterials 2021, 11,
2337. https://doi.org/10.3390/
nano11092337
Academic Editor: Daniela Iannazzo
Received: 23 August 2021
Accepted: 6 September 2021
Published: 8 September 2021
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4.0/).
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and
Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen,
91054 Erlangen, Germany; Iwona.Cicha@uk-erlangen.de (I.C.); christoph.alexiou@uk-erlangen.de (C.A.)
* Correspondence: ralf.friedrich@uk-erlangen.de
Abstract:
In recent years, many promising nanotechnological approaches to biomedical research have
been developed in order to increase implementation of regenerative medicine and tissue engineering
in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased
or injured tissues is considered advantageous in most areas of medicine. In particular, for the
treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of
functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing,
nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix
and promote adhesion or differentiation of cells. This review focuses on the latest developments
in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue
engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation
methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to
their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds,
such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct
IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell
type through mechanotransduction.
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