Astrocyte research has been out there for years. Has your doctor done anything with it? If not, you don't have a functioning stroke doctor or hospital.
astrocytes (95 posts to June 2011)
Do you prefer your doctor and hospital incompetence NOT KNOWING? OR NOT DOING?
Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential
Jueling Liu and Yuying Guo contributed equally to this work.
Abstract
In the central nervous system (CNS), a large group of glial cells called astrocytes play important roles in both physiological and disease conditions. Astrocytes participate in the formation of neurovascular units and interact closely with other cells of the CNS, such as microglia and neurons. Stroke is a global disease with high mortality and disability rate, most of which are ischemic stroke. Significant strides in understanding astrocytes have been made over the past few decades. Astrocytes respond strongly to ischemic stroke through a process known as activation or reactivity. Given the important role played by reactive astrocytes (RAs) in different spatial and temporal aspects of ischemic stroke, there is a growing interest in the potential therapeutic role of astrocytes. Currently, interventions targeting astrocytes, such as mediating astrocyte polarization, reducing edema, regulating glial scar formation, and reprogramming astrocytes, have been proven in modulating the progression of ischemic stroke. The aforementioned potential interventions on astrocytes and the crosstalk between astrocytes and other cells of the CNS will be summarized in this review.
No comments:
Post a Comment