Noninvasive Associative Plasticity Induction in a Corticocortical Pathway of the Human Brain
http://www.jneurosci.org/content/31/48/17669.abstract
Abstract
Coincident pairing of presynaptic and
postsynaptic activity selectively strengthens synaptic connections, a
key mechanism
underlying cortical plasticity. Using paired
associative transcranial magnetic stimulation (TMS), we demonstrate
selective
potentiation of physiological connectivity
between two human brain regions, ventral premotor cortex (PMv) and
primary motor
cortex (M1) after repeated paired-pulse TMS of
PMv and M1. The effect was anatomically specific: paired stimulation of
the
presupplementary motor area and M1 did not
induce changes in PMv–M1 pathway connectivity. The effect was dependent
on stimulation
order: repeated stimulation of PMv before M1 led
to strengthening of the PMv–M1 pathway, while repeated stimulation of
M1
before PMv diminished the strength of the PMv–M1
pathway. The expression of the change in the pathway depended on the
cognitive
state of the subject at the time of testing:
when the subject was tested at rest, paired PMv–M1 stimulation led to an
increased
inhibitory influence of PMv over M1, but when
the subject was tested while engaged in a visuomotor task, PMv–M1
stimulation
led to an increased facilitatory influence of
PMv over M1. Plasticity evolved rapidly, lasted for at least 1 h, and
began
to reverse 3 h after intervention.
Ask your doctor to intrepret this and apply it to your therapy. If they don't have the full copy, throw a hissy fit and demand to know why they are so out-of-date and unknowledgeable
http://www.jneurosci.org/content/32/17/5705.full.pdf+html
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