I know Vioxx was pulled from the market but this gives a good understanding why heart attack and strokes increased. The more knowledge the better.
http://blogs.wsj.com/health/2012/05/02/studies-shine-light-on-how-vioxx-raises-heart-risks/
In 2004, Merck pulled the popular pain medication Vioxx from the
market, after a study showed it doubled the risk of heart attack or
stroke.
Now we know more about what caused these side effects, according to researchers at the University of Pennsylvania’s Perelman School of Medicine.
Their conclusion: In trying to relieve pain, these drugs also
suppress the production of enzymes that play a key role protecting the
heart.
In the journal Science Translational Medicine today, the researchers published the last of some 20 studies in humans and mice
examining the biological underpinnings for the cardiovascular risks
from taking Vioxx and related drugs. The label for Pfizer’s Celebrex,
the only drug in the class still on the market, warns about the risks.
These drugs aimed to provide pain relief without causing the bleeding
ulcers that could result from taking other painkillers. They’d do that
by blocking a single enzyme, called Cox-2, that makes fats that cause
pain.
Yet one of these fats protects the heart. Blocking Cox-2’s production
turns out to have a cascade of biological effects that raise the
cardiovascular risk even among healthy patients, says Garret FitzGerald, director of Penn’s Institute for Translational Medicine and Therapeutics.
For instance, blocking Cox-2 suppresses production of molecules that
protect the heart by breaking up potential clots and promoting blood
flow.
Merck said in a email that it hadn’t had an opportunity to thoroughly
review the mice-study data released today, but that “experience has
shown that the results of animal studies do not always translate well
into humans.”
Pfizer said a study in genetically-modified mice isn’t sufficient to
“draw conclusions” about the benefits and risks of Celebrex, and the
company is conducting a clinical trial in patients to assess the drug’s
long-term cardiovascular risk. “Since 2005 the FDA has required that all
prescription NSAIDs, non-selective and COX-2 selective, carry the same
warnings for potential cardiovascular risk,” the company said in a
statement.
A study published last month in the Proceedings of the National Academy of Sciences
showed how suppressing Cox-2 causes hardening of arteries in mice. That
explains why clinical testing of the drugs indicated they can raise the
heart risks even among healthy patients who are taking the drugs for
more than a year, FitzGerald says.
With a theory explaining why drugs like Vioxx can be dangerous,
FitzGerald says a consortium of researchers is now exploring ways to
identify patients who could benefit from taking one of the drugs without
great risk
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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