Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, May 2, 2012

Studies Shine Light on How Vioxx Raises Heart Risks

I know Vioxx was pulled from the market but this gives a good understanding why heart attack and strokes increased. The more knowledge the better.
http://blogs.wsj.com/health/2012/05/02/studies-shine-light-on-how-vioxx-raises-heart-risks/
In 2004, Merck pulled the popular pain medication Vioxx from the market, after a study showed it doubled the risk of heart attack or stroke.
Now we know more about what caused these side effects, according to researchers at the University of Pennsylvania’s Perelman School of Medicine.
Their conclusion: In trying to relieve pain, these drugs also suppress the production of enzymes that play a key role protecting the heart.
In the journal Science Translational Medicine today, the researchers published the last of some 20 studies in humans and mice examining the biological underpinnings for the cardiovascular risks from taking Vioxx and related drugs. The label for Pfizer’s Celebrex, the only drug in the class still on the market, warns about the risks.
These drugs aimed to provide pain relief without causing the bleeding ulcers that could result from taking other painkillers. They’d do that by blocking a single enzyme, called Cox-2, that makes fats that cause pain.
Yet one of these fats protects the heart. Blocking Cox-2’s production turns out to have a cascade of biological effects that raise the cardiovascular risk even among healthy patients, says Garret FitzGerald, director of Penn’s Institute for Translational Medicine and Therapeutics.
For instance, blocking Cox-2 suppresses production of molecules that protect the heart by breaking up potential clots and promoting blood flow.
Merck said in a email that it hadn’t had an opportunity to thoroughly review the mice-study data released today, but that “experience has shown that the results of animal studies do not always translate well into humans.”
Pfizer said a study in genetically-modified mice isn’t sufficient to “draw conclusions” about the benefits and risks of Celebrex, and the company is conducting a clinical trial in patients to assess the drug’s long-term cardiovascular risk. “Since 2005 the FDA has required that all prescription NSAIDs, non-selective and COX-2 selective, carry the same warnings for potential cardiovascular risk,” the company said in a statement.
A study published last month in the Proceedings of the National Academy of Sciences showed how suppressing Cox-2 causes hardening of arteries in mice. That explains why clinical testing of the drugs indicated they can raise the heart risks even among healthy patients who are taking the drugs for more than a year, FitzGerald says.
With a theory explaining why drugs like Vioxx can be dangerous, FitzGerald says a consortium of researchers is now exploring ways to identify patients who could benefit from taking one of the drugs without great risk

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