I want better cognition since I am adult, not aged, so get those human clinical trials going.
http://www.ncbi.nlm.nih.gov/pubmed/23274840
Abstract
Age-related priming of microglia and release of
inflammatory cytokines, such as interleukin-1β (IL-1β) and
interleuekin-6 (IL-6) have been associated with deficits in cognitive
function. The present study assessed whether treatment with minocycline
could improve spatial cognition in aged mice, and whether these
improvements in behavior were associated with reduced microglia
activation and an enhancement in hippocampal neurogenesis. Adult (3
months) and aged (22 months) male BALB/c mice received minocycline in
their drinking water or control mice received distilled water for 20
days. Mice received BrdU to label dividing cells on days 8-17. Spatial
learning was measured using the water maze. Immunohistochemistry was
conducted to measure number of BrdU positive neurons and number and size
of microglia by detection of Iba-1 in the dentate gyrus molecular
layer. Further, hippocampal samples were collected to measure changes in
IL-1β, IL-6, and CD74 expression. The data show that aged mice have
increased hippocampal expression of IL-1β, IL-6, and CD74 relative to
adults. Minocycline treatment significantly improved acquisition of the
water maze in aged mice but not adults. Minocycline reduced the average
size of Iba-1 positive cells and total Iba-1 counts, but did not affect
hippocampal cytokine gene expression.
Minocycline increased neurogenesis
in adults but not aged mice. Collectively, the data indicate that
treatment with minocycline may recover some aspects of cognitive decline
associated with aging, but the effect appears to be unrelated to adult
hippocampal neurogenesis.
No comments:
Post a Comment