http://nro.sagepub.com/content/19/2/175.abstract?etoc
Abstract
Intracellular pathways related to cell
survival regulate neuronal physiology during development and
neurodegenerative disorders.
One of the pathways that have recently emerged with
an important role in these processes is nuclear factor-κB (NF-κB). The
activity of this pathway leads to the nuclear
translocation of the NF-κB transcription factors and the regulation of
anti-apoptotic
gene expression. Different stimuli can activate the
pathway through different intracellular cascades (canonical,
non-canonical,
and atypical), contributing to the translocation of
specific dimers of the NF-κB transcription factors, and each of these
dimers can regulate the transcription of different
genes. Recent studies have shown that the activation of this pathway
regulates
opposite responses such as cell survival or
neuronal degeneration. These apparent contradictory effects depend on
conditions
such as the pathway stimuli, the origin of the
cells, or the cellular context. In the present review, the authors
summarize
these findings and discuss their significance with
respect to survival or death in the nervous system.
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