For your doctor and researcher to answer how this might help your recovery. No self-precribing.
Lucky rats.
Early growth hormone (GH) treatment promotes relevant motor functional improvement after severe frontal cortex lesion in adult rats
Abstract
A
number of studies, in animals and humans, describe the positive effects
of the growth hormone (GH) treatment combined with rehabilitation on
brain reparation after brain injury. We examined the effect of GH
treatment and rehabilitation in adult rats with severe frontal motor
cortex ablation. Thirty-five male rats were trained in the
paw-reaching-for-food task and the preferred forelimb was recorded.
Under anesthesia, the motor cortex contralateral to the preferred
forelimb was aspirated or sham-operated. Animals were then treated with
GH (0.15 mg/kg/day, s.c) or vehicle during 5 days, commencing
immediately or 6 days post-lesion. Rehabilitation was applied at short-
and long-term after GH treatment. Behavioral data were analized by ANOVA
following Bonferroni post hoc test. After sacrifice,
immunohistochemical detection of glial fibrillary acid protein (GFAP)
and nestin were undertaken in the brain of all groups.
Animal
group treated with GH immediately after the lesion, but not any other
group, showed a significant improvement of the motor impairment induced
by the motor lesion, and their performances in the motor test were no
different from sham-operated controls.
GFAP
immunolabeling and nestin immunoreactivity were observed in the
perilesional area in all injured animals; nestin immunoreactivity was
higher in GH-treated injured rats (mainly in animals GH-treated 6 days
post-lesion). GFAP immunoreactivity was similar among injured rats.
Interestingly, nestin re-expression was detected in the contralateral
undamaged motor cortex only in GH-treated injured rats, being higher in
animals GH-treated immediately after the lesion than in animals
GH-treated 6 days post-lesion.
Early GH treatment
induces significant recovery of the motor impairment produced by frontal
cortical ablation. GH effects include increased neurogenesis for
reparation (perilesional area) and for increased brain plasticity
(contralateral motor area).
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