This might be difficult for your doctor to acquire the day you have a stroke so you better tell your doctor to stock up.
http://www.newswise.com/articles/saneron-and-henry-ford-health-cell-therapy-combo-aids-stroke
Researchers at the Henry Ford Health System (Detroit, MI) and
colleagues at Saneron CCEL Therapeutics, Inc. of Tampa, Florida, have
found that when human umbilical cord blood cells (HUCBCs) were
transplanted into test rats modeled with stroke, the addition of
Simvastatin to the HUCBCs significantly increased the therapeutic
benefit of the HUCBCs.
The study was published in a recent issue of Neuroscience (227:223-231)
According
to N. Kuzmin-Nichols, Saneron president and COO, the combination
treatment, delivered 24 hours after the test animals were subjected to
simulated stroke, showed an interactive effect in improving neurological
outcome. When compared with monotherapy, the combination therapy
increased densities of key blood vessels, arteries, and smooth muscle
cells in vascular walls.
“HUCBCs are a source for blood stem
cells, endothelial cell precursors, mensenchymal cell progenitors, and
other multipotent and pluripotent stem cells,” said Kuzmin-Nichols.
“They offer a promising therapy for stroke. However, when HUCBCs are
used alone, and injected via a vascular route for brain repair, success
has been limited.”
Because the drug Simvastatin has been
demonstrated to be a neurorestorative and neuroprotective agent in
ischemic brain injury, the research team hypothesized that the
combination of therapeutic doses of Simvastatin and HUCBCs would
increase the expression of Angiopoietin-1(Ang-1, a protein with
important roles in vascular development and blood vessel growth) and its
receptor Tie2 (a cell-surface receptor that binds with Ang-1). Both
Ang-1 and Tie2 promote vascular stabilization and artery growth and
could enhance blood vessel remodeling (angiogenesis) after stroke, said
the researchers.
According to the researchers, HUCBCs contain a
“ready supply” of neurotrophic and angiogenic factors that induce
neurogenesis (neural cell repair) and angiogenesis (blood vessel
growth), both of which are critical to promoting neurological recovery
post stroke. While transplanted HUCBCs have been found to selectively
migrate to the injured brain, past and recent research has discovered
that few transplanted HUCBCs express neural cell characteristics, and
few find their way to the ischemic region of the brain.
“Our study
using subtherapeutic monotherapy doses did not show significant
improvement in either vasculogenesis or functional outcome,” said Dr.
Jieli Chen of Henry Ford Hospital and the study corresponding author.
“However, the combination of HUCBCs and Simvastatin did show an
interactive effect with a significant improvement in neurological
outcome. The combination also amplified endogenous angiogenesis and
arteriogenesis, and enhanced vascular remodeling.”
Their in vitro
experiments showed that combination treatment and Ang-1 significantly
increased capillary-like tube formation and arterial cell migration
while anti-Ang-1 significantly reduced combination treatment-induced
tube formation and artery cell migration.
Dr. Chen noted that
combination treatment likely increases the signaling between the brain
vasculature and parenchymal cells that facilitate the migration of
HUCBCs into the injured cerebral tissue. This signaling may be
attributed to the increased expression of stromal derived factor (SDF-1)
in brain vascular and parenchymal cells and its receptor (CXCR4) in
HUCBCs.
The researchers concluded that their findings “indicate
that the combination of sub-therapeutic doses of Simvastatin and HUCBCs
increases Ang1/Tie2 and thereby enhances vascular remodeling that
contribute to improved functional outcome after stroke.”
“Our
results in this preclincial study support further exploration of the use
of combination therapies - such as those combining Simvastatin and
HUCBCs - for stroke treatment,” said Kuzmin-Nichols.
Funding for
the study came from grants from the National Institute on Aging, RO1
AG031811,National Institute of Neurological Disorder and Stroke, PO1
NS23393 and 1R41NS064708, and from the American Heart Association, grant
09GRNT2300151.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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