Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, October 7, 2013

A Model of Persistent Learned Nonuse Following Focal Ischemia in Rats

I disagree that they even know what learned non-use is.  They haven't proved that the problem is that the area of the brain has the ability and that ability disappears. Or, is it from a dead area that has no ability to move  and thus wrongly assign non-use as the problem. This is an incredibly easy statement for therapists to use to deflect blame for not recovering back onto the patient rather than having a detailed enough diagnosis to know what is easily recoverable vs. not easily recoverable.
http://nnr.sagepub.com/content/27/9/900.abstract?etoc
  1. Crystal L. MacLellan, MScPT, PhD1
  2. Kristopher D. Langdon, PhD2,3
  3. Alex Botsford, BSc2
  4. Stephanie Butt, BSc2
  5. Dale Corbett, PhD2,3,4,5
  1. 1University of Alberta, Edmonton, AB, Canada
  2. 2Memorial University of Newfoundland, St John’s, NF, Canada
  3. 3Heart and Stroke Foundation Centre for Stroke Recovery, Ottawa, ON, Canada
  4. 4University of Ottawa, ON, Canada
  5. 5University of Toronto, ON, Canada
  1. Crystal L. MacLellan, MScPT, PhD, Department of Physical Therapy, University of Alberta, 2-50 Corbett Hall, Edmonton, AB, T6G 2G4, Canada. Email: clmac@ualberta.ca

Abstract

Background. After hemiplegic stroke, people often rely on their unaffected limb to complete activities of daily living. A component of residual motor dysfunction involves learned suppression of movement, termed learned nonuse. 

Objective. To date, no rodent stroke model of persistent learned nonuse has been described that can facilitate understanding of this phenomenon and test interventions to overcome it.  

Methods. Rats were trained in the staircase skilled-reaching and limb use asymmetry (cylinder) tasks. Endothelin-1 was injected into the cortex and striatum to create focal ischemia. Starting 7 days poststroke, half of the rats (ipsilateral training; n = 15) were trained to reach for food reward pellets in the tray-reaching task with the ipsilateral forelimb. Training lasted 20 days. Rats in the control group (control; n = 15) did not receive training. All rats then remained in their home cages for an additional 30 days. Performance on the cylinder and staircase tasks was assessed ~2 months poststroke.  

Results. Ischemia caused significant functional impairments in all rats. Significant contralateral forelimb skilled-reaching recovery was evident in the control group at 2 months but not the ipsilateral training group. There was no difference in performance in the cylinder task. Similarly, the volume of brain injury (~66 mm3) was similar between groups. Ipsilateral forelimb training reduced poststroke motor recovery. Conclusion. This rodent model of persistent nonuse after stroke may be used to further understand mechanisms of learned nonuse as well as to evaluate pharmacological and rehabilitation treatments to overcome it.

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