Deans' stroke musings: Theranostic Quantum Dots for Crossing Blood-Brain Barrier in vitro and Providing Therapy of HIV-associated Encephalopathy

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, October 25, 2013

Theranostic Quantum Dots for Crossing Blood-Brain Barrier in vitro and Providing Therapy of HIV-associated Encephalopathy

Blow your doctors mind away and ask when Quantum dots are going to be used to deliver neuroprotective drugs thru the blood brain barrier. Ask for a detailed explanation of how Schrodingers cat gets reduced in size to a quantum dot.
http://www.frontiersin.org/Journal/10.3389/fphar.2013.00140/abstract

Gaixia Xu¹, Supriya Mahajan², Indrajit Roy³ and Ken-Tye Yong^4*

¹ College of Optoelectronic Information Engineering, Shenzhen University, China
²Department of Medicine, Division of Allergy, Immunology and Rheumatology, The State University of New York at Buffalo, USA
³Department of Chemistry, University of Delhi, India
⁴School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore

The blood-brain barrier (BBB) is a complex physiological checkpoint that restricts the free diffusion of circulating molecules from the blood into the central nervous system (CNS). Delivering of drugs and other active agents across the blood brain barrier (BBB) is one of the major technical challenges faced by scientists and medical practitioners. Therefore, development of novel methodologies to address this challenge holds the key for both the diagnosis and treatment of brain diseases, such as HIV-associated encephalopathy (HIVE). Bioconjugated Quantum dots (QDs) are excellent fluorescent probes and nano-vectors, being designed to transverse across the BBB and visualize drug delivery inside the brain. This paper discusses the use of functionalized quantum dots for crossing the blood brain barrier and treating brain disease. We highlight the guidelines for using in vitro BBB models for brain disease studies. The theranostic QDs offers a strategy to significantly improve the effective dosages of drugs to transverse across the BBB and orientate to the targets inside the brain.