Well, what is the similar answer for stroke? Is your stroke association going to do anything about this?
To cite this article:Ryan J. Waters, Gordon D. Murray, Graham M. Teasdale, Janice Stewart, Ian Day, Robert J. Lee, and James A.R. Nicoll. Journal of Neurotrauma. October 15, 2013, 30(20): 1710-1716. doi:10.1089/neu.2012.2792.
Published in Volume: 30 Issue 20: October 10, 2013
ABSTRACT
Clinical
outcome after traumatic brain injury (TBI) is variable and cannot
easily be predicted. There is increasing evidence to suggest that there
may be genetic influences on outcome. Cytokines play an important role
in mediating the inflammatory response provoked within the central
nervous system after TBI. This study was designed to identify
associations between cytokine gene polymorphisms and clinical outcome 6
months after head injury. A prospectively identified cohort of patients (n=1096,
age range 0–93 years, mean age 37) was used. Clinical outcome at 6
months was assessed using the Glasgow Outcome Scale. In an initial
screen of 11 cytokine gene single nucleotide polymorphisms (SNPs)
previously associated with disease susceptibility or outcome (TNFA −238
and −308, IL6 −174, −572 and −597, IL1A −889, IL1B −31, −511 and +3953,
and TGFB −509 and −800), TNFA −308 was identified as having a likely
association. The TNFA −308 SNP was further evaluated, and a significant
association was identified, with 39% of allele 2 carriers having an
unfavorable outcome compared with 31% of non-carriers (adjusted odds
ratio 1.67, confidence interval 1.19–2.35, p=0.003). These
findings are consistent with experimental and clinical data suggesting
that neuroinflammation has an impact on clinical outcome after TBI and
that tumor necrosis factor alpha plays an important role in this
process.
No comments:
Post a Comment