http://www.medpagetoday.com/Endocrinology/GeneralEndocrinology/50467?
Researchers found a reverse J-shaped association between vitamin D and cardiovascular-related mortality -- with a stronger association for those with low levels of the hormone.
In a modeling study based on an observational cohort study of nearly 250,000 people, those with low 25-hydroxyvitamin D levels -- on the order of 12.5 nmol/L -- had a hazard ratio for cardiovascular disease mortality of 2.0 (95% CI 1.8-2.1) compared with members who had levels of 70 nmol/L (those with the lowest mortality risk).
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Men with low 25-OH-D levels were at greater risk (HR 2.5,
95% CI 2.2-2..9) than were women with low levels (HR 1.7, 95% CI
1.5-1.9), according to the study, published online in the Journal of Clinical Endocrinology and Metabolism. More surprising, perhaps, was that those at very high levels -- about 125 nmol/L -- also faced increased cardiovascular mortality risk, with a hazard ratio of 1.3 (95% CI 1.2-1.4) relative to the 70-nmol/L group, said Darshana Durup, PhD, at the Department of Drug Design and Pharmacology at the University of Copenhagen, in Denmark, and colleagues.
But the researchers recognized that the study was limited. "Sufficient data are not available to draw firm conclusions on the relationship between 25-hydroxyvitamin D and cardiovascular disease mortality at the extremes, especially at the higher extremes," they wrote.
Read the rest at the link and don't do anything based on this without talking to your doctor.
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