http://tan.sagepub.com/content/9/1/9?etoc
Abstract
Spasticity, one of the main symptoms of
multiple sclerosis (MS), can affect more than 80% of MS patients during
the course
of their disease and is often not treated
adequately. δ-9-Tetrahydrocannabinol-cannabidiol (THC-CBD) oromucosal
spray is a
plant-derived, standardized cannabinoid-based
oromucosal spray medicine for add-on treatment of moderate to severe,
resistant
multiple sclerosis-induced spasticity. This article
reviews the current evidence for the efficacy and safety, with
dizziness
and fatigue as the most common treatment-related
adverse events, being mostly mild to moderate in severity. Results from
both
randomized controlled phase III studies involving
about,1600 MS patients or 1500 patient-years and recently published
studies
on everyday clinical practice involving more than
1000 patients or more than,1000 patient-years are presented.
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