Deans' stroke musings: Oxidative theory of atherosclerosis and antioxidants

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, December 26, 2015

Oxidative theory of atherosclerosis and antioxidants

How is your doctor going to use this to stop and reverse your atherosclerosis?
http://www.sciencedirect.com/science/article/pii/S0300908415004289

Dedicated to the memory of L. Douste-Blazy (MD, DrSc, Professor of Biochemistry, Faculty of Medicine, University of Toulouse, France).

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doi:10.1016/j.biochi.2015.12.014

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Highlights

•: Atherosclerosis is a universal process in humans. Brief picture of Atherogenesis.
•: The 'Lipid theory of atherosclerosis'. From early discoveries to modern era: cholesterol, LDL receptor and scavenger receptor pathways.
•: The 'oxidative theory of atherosclerosis'. Free radicals, Reactive oxygen species, LDL oxidation, biological properties and potential role of oxidized LDLs in atherogenesis.
•: Antioxidants are effective to prevent LDL oxidation and delay atherogenesis in animal models, but do not prevent myocardial infarction and coronary heart disease death in humans.
•: The 'Mediterranean diet' seems to be protective against cardiovascular events and death.

Abstract

Atherosclerosis is a multifactorial process that begins early in infancy and affects all the humans. Early steps of atherogenesis and the evolution towards complex atherosclerotic plaques are briefly described. After a brief history of the 'Lipid theory of atherosclerosis', we report the most prominent discoveries on lipoproteins, their receptors and metabolism, and their role in atherogenesis. The main focus is the 'oxidative theory of atherosclerosis', with emphasis on free radicals and reactive oxygen species, lipid peroxidation and LDL oxidation, biological properties of oxidized LDL and their potential role in atherogenesis. Then, we report the properties of antioxidants and antioxidant systems and their effects in vitro, on cultured cells, in animal models and in humans. The surprising discrepancy between the efficacy of antioxidants in vitro and in animal model of atherosclerosis and the lack of protective effect against cardiovascular events and death in epidemiological study and clinical trials are discussed. In contrast, epidemiological studies seem to indicate that the Mediterranean diet may protect (in part) against atherosclerosis complications (myocardial infarction and cardiovascular death).

Graph from here: