http://anp.sagepub.com/content/50/1/46.abstract?
- 1Department of Psychiatry, Sozialstiftung Bamberg, Bamberg, Germany
- 2Department of Physiological Psychology, Otto-Friedrich-Universität Bamberg, Bamberg, Germany
- 3Centre for Psychiatry, Justus Liebig University School of Medicine Gießen, Gießen, Germany
- Wolfgang Trapp, Department of Psychiatry, Sozialstiftung Bamberg, St-.Getreu-Straße 18, 96049 Bamberg, Germany. Email: wolfgang.trapp@sozialstiftung-bamberg.de
Abstract
Objective:
Neurocognitive deficits that persist despite antidepressive treatment
and affect social and vocational functioning are well
documented in major depressive disorder.
Cognitive training approaches have proven successful in ameliorating
these deficits
in other psychiatric groups, but very few
studies have been conducted in unipolar depressive patients by now. In
contrast
to previous studies solely including
outpatients, effects of a cognitive remediation intervention on
neurocognitive functioning
of depressed inpatients were assessed by the
present study.
Method: A randomized
controlled trial was carried out with 46 depressed inpatients of a
psychiatric hospital. Patients were randomly
assigned to either a control group that received
standard drug and non-drug (cognitive behavioural, occupational,
sports,
relaxation and music therapy) antidepressive
treatment or a remediation group that additionally received 12 sessions
of cognitive
training for a total of 4 weeks (three sessions
per week). An intent to treat analysis and a last observation carried
forward
method was used for data analyses.
Results: Patients of the remediation group demonstrated greater improvements in neurocognitive measures of verbal and nonverbal memory,
working memory and executive function (Cohen’s d effect sizes between .52 and .98).
Conclusions: These
results provide preliminary evidence that cognitive remediation
interventions can be successfully applied also in psychiatric
inpatients experiencing an acute depressive
episode.
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