Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, May 21, 2016

The Use of Doublecortin to Quantify the Effects of Pharmacological Treatment on Neurogenesis and Functional Recovery after Stroke

A thesis but your doctor needs to get this updated to the stroke strategy.  Only 71 pages. I know there is no strategy anyplace but if your stroke department head is not communicating with other heads to create one then you have an incompetent stroke department head. And stroke survivors are negatively affected by that incompetence. Without a change your children and grandchildren will be screwed.

The Use of Doublecortin to Quantify the Effects of Pharmacological Treatment on Neurogenesis and Functional Recovery after Stroke

Ischemic strokes account for 87% of all strokes and
can have debilitating effects on language, sensory, and motor skills. Currently, tPA is the only medication approved by the FDA for the treatment of ischemic stroke, but the window of time to administer the drug is very small. In this thesis, we investigate the use of a simvastatin and fluoxetine
drug combination (FS) as a possible alternative treatment for ischemic stroke victims. To analyze the effects of FS on neurogenesis and functional recovery, we utilize the Montoya Staircase and quantify the amount of neurogenesis using doublecortin. Although the results of this study show that the drug treatment did not produce the significant increase in neurogenesis when comparing the control with the drug-treated animals as we had hoped for, nor did it translate to an increase in functional recovery, there was significantly more neurogenesis in the right hemisphere in the anterior and middle region
of the subventricular zone (SVZ) of the FS rats than the left. This tells us that the drug treatment did produce a significant amount of neurogenesis in the SVZ, but further work needs to be done to better understand how the FS
drug treatment effects neurogenesis and functional recovery. There may be an optimal window of time and dosage that will lead to a greater significance in recovery and higher levels of neurogenesis. This could open the door for a better treatment option to increase the quality of life for ischemic stroke patients.

 

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