Do we have any idea what the levels of various markers are supposed to be in survivors compared to normals? An extremely simple question to answer but it won't be because we have fucking failures for stroke associations.
http://dgnews.docguide.com/lower-levels-coenzyme-q10-blood-associated-multiple-system-atrophy?
The neurodegenerative disease known as multiple system atrophy (MSA)
affects both movement and involuntary bodily functions. Questions have
been raised about the potential role of coenzyme Q10 (CoQ10)
insufficiency in the development of MSA. Little is known about blood
levels of CoQ10 in patients carrying either COQ2 mutations or no
mutations.
Shoji Tsuji, MD, PhD, the University of Tokyo, Tokyo, Japan, and
coauthors explored whether there are associations of levels of CoQ10 in
the blood and MSA, in a new article published online by JAMA Neurology.
The study included 44 Japanese patients with MSA (average age almost
64) and, for comparison, 39 Japanese control patients (average age about
60).
The authors report their data showed decreased levels of blood CoQ10
in patients was associated with MSA regardless of the COQ2 genotype. The
authors suggest this may support the idea that CoQ10 supplementation
may be beneficial for patients with MSA. However, they acknowledge study
limitations and caution that more studies are needed.
“Prospective cohort studies are warranted to determine the
longitudinal effects of plasma levels of CoQ10 on the development of
MSA. Furthermore, future clinical trials of supplementation with CoQ10
in patients with MSA are required to confirm our hypothesis,” the
article concludes.
SOURCE: JAMA Neurology
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