http://f1000research.com/articles/5-1467/v1
This article is included in the F1000 Faculty Reviews channel.
Abstract
Stroke continues to be a major
cause of adult disability. In contrast to progress in stroke prevention
and acute medical management, there have been no major breakthroughs in
rehabilitation therapies. Most stroke rehabilitation trials are
conducted with patients at the chronic stage of recovery and this limits
their translation to clinical practice. Encouragingly, several
multi-centre rehabilitation trials, conducted during the first few weeks
after stroke, have recently been reported; however, all were negative.
There is a renewed focus on improving the quality of stroke
rehabilitation research through greater harmonisation and
standardisation of terminology, trial design, measures, and reporting.
(Shit, you idiots you solve for exactly how neuroplasticity or neurogenesis is repeatable. Quit thinking microscopic.)However, there is also a need for more pragmatic trials to test
interventions in a way that assists their translation to clinical
practice. Novel interventions with a strong mechanistic rationale need
to be tested in both explanatory and pragmatic trials if we are to make a
meaningful difference to stroke rehabilitation practice and outcomes.
Corresponding author: Cathy M. Stinear How to cite: Stinear CM. Stroke rehabilitation research needs to be different to make a difference [version 1; referees: 2 approved]. F1000Research 2016, 5(F1000 Faculty Rev):1467 (doi: 10.12688/f1000research.8722.1) Copyright: © 2016 Stinear CM. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Competing interests: The author is a member of the Stroke Recovery and Rehabilitation Roundtable.
First published: 22 Jun 2016, 5(F1000 Faculty Rev):1467 (doi: 10.12688/f1000research.8722.1) Latest published: 22 Jun 2016, 5(F1000 Faculty Rev):1467 (doi: 10.12688/f1000research.8722.1)
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