Nuts and peanuts, but not peanut butter, may protect against death from cancer, heart disease, respiratory disease, and other major causes
- 1Hospital Clínic de Barcelona, Spain
- 2Loma Linda University, USA
Methods: The primary aim of WAHA is to examine the effects of ingesting walnuts daily for 2 years on cognitive function and retinal health, assessed with a battery of neuropsychological tests and optical coherence tomography, respectively. All participants followed their habitual diet, adding walnuts at 15% of energy (~30-60 g/d) (walnut group) or abstaining from walnuts (control group). Secondary outcomes include changes in adiposity, blood pressure, and serum and urinary biomarkers in all participants and brain magnetic resonance imaging in a subset.
Results: From May 2012 to May 2014, 708 participants (mean age 69 years, 68% women) were randomized. The study ended in May 2016 with a 90% retention rate. Discussion: The results of WAHA might provide high-level evidence of the benefit of regular walnut consumption in delaying the onset of age-related cognitive impairment and retinal pathology. The findings should translate into public health policy and sound recommendations to the general population. (ClinicalTrials.gov identifier NCT01634841).
Citation: Rajaram S, Valls-Pedret C, Cofan M, Sabaté J, Serra-Mir M, Pérez-Heras A, Arechiga A, Casaroli-Marano R, Alforja S, Sala-Vila A, Doménech M, Roth I, Freitas-Simoes T, Calvo C, López-Illamola A, Haddad E, Kazzi N, Huey L, Fan J, Bitok E and Ros E (2016). The Walnuts and Healthy Aging study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging. Front. Aging Neurosci. 8:333. doi: 10.3389/fnagi.2016.00333