I bet our fucking failures of stroke associations won't lead the charge to get this into general use. In fact I bet they do absolutely nothing. I wonder if they know which of these 5 causes of neuronal cascade of death this intervention ameliorates? Or was this just pure luck rather than following any sort of strategy?
http://www.medicnewsweb.com/stroke-treatment/
By Dr. Heather on
Researchers at
The University of Manchester have discovered that a potential new drug
for stroke treatment reduces the number of brain cells destroyed by
stroke and then helps to repair the damage.A reduction in blood flow to
the brain caused by stroke is a major cause of death and disability, and
there are few effective treatments.A team of scientists at The
University of Manchester has now found that a potential new stroke drug
not only works in rodents by limiting the death of existing brain cells
but also by promoting the birth of new neurons (so-called neurogenesis).
This
finding provides further support for the development of this
anti-inflammatory drug, interleukin-1 receptor antagonist (IL-1Ra in
short), as a new stroke treatment. The drug is already licensed for use
in humans for some conditions, including rheumatoid arthritis. Several
early stage clinical trials in stroke with IL-1Ra have already been
completed in Manchester, though it is not yet licensed for this
condition.In the research, published in the biomedical journal Brain,
Behavior and Immunity, the researchers show that in rodents with a
stroke there is not only reduced brain damage early on after the stroke,
but several days later increased numbers of new neurons, when treated
with the anti-inflammatory drug IL-1Ra.Previous attempts to find a drug
to prevent brain damage after stroke have proved unsuccessful and this
new research offers the possibility of a new treatment.Importantly, the
use of IL-1Ra might be better than other failed drugs in stroke as it
not only limits the initial damage to brain cells, but also helps the
brain repair itself long-term through the generation of new brain cells.
These
new cells are thought to help restore function to areas of the brain
damaged by the stroke. Earlier work by the same group showed that stroke
treatment with IL-1Ra does indeed help rodents regain motor skills that
were initially lost after a stroke. Early stage clinical trials in
stroke patients also suggest that IL-1Ra could be beneficial.The current
research is led by Professor Stuart Allan, who commented: “The results
lend further strong support to the use of IL-1Ra in the stroke
treatment, however further large trials are necessary.”
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