No association, which will never get thru our legislators thick skulls.
Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke
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Abstract
Background and Purpose—Current
knowledge on cannabis use in relation to stroke is based almost
exclusively on clinical reports. By using a population-based cohort, we
aimed to find out whether there was an association between cannabis use
and early-onset stroke, when accounting for the use of tobacco and
alcohol.
Methods—The
cohort comprises 49 321 Swedish men, born between 1949 and 1951, who
were conscripted into compulsory military service between the ages of 18
and 20. All men answered 2 detailed questionnaires at conscription and
were subject to examinations of physical aptitude, psychological
functioning, and medical status. Information on stroke events up to ≈60
years of age was obtained from national databases; this includes strokes
experienced before 45 years of age.
Results—No
associations between cannabis use in young adulthood and strokes
experienced ≤45 years of age or beyond were found in multivariable
models: cannabis use >50 times, hazard ratios=0.93 (95% confidence
interval [CI], 0.34–2.57) and 0.95 (95% CI, 0.59–1.53). Although an
almost doubled risk of ischemic stroke was observed in those with
cannabis use >50 times, this risk was attenuated when adjusted for
tobacco usage: hazards ratio=1.47 (95% CI, 0.83–2.56). Smoking ≥20
cigarettes per day was clearly associated both with strokes before 45
years of age, hazards ratio=5.04 (95% CI, 2.80–9.06), and with strokes
throughout the follow-up, hazards ratio=2.15 (95% CI, 1.61–2.88).
Conclusions—We
found no evident association between cannabis use in young adulthood
and stroke, including strokes before 45 years of age. Tobacco smoking,
however, showed a clear, dose–response shaped association with stroke.
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