Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Monday, January 23, 2017

Transplanted neurons incorporated into a stroke-injured rat brain

Finally someone actually proved stem cells survived and helped. Now followup on humans, maybe in 50 years since we have NO stroke leadership to go to and NO strategy for following up promising research. But this still seems to require some functioning neurons, not truly able to do the functions that existed in the dead brain area. Ah well, baby steps.
https://m.medicalxpress.com/news/2017-01-transplanted-neurons-incorporated-stroke-injured-rat.html
Today, a stroke usually leads to permanent disability – but in the future, the stroke-injured brain could be reparable by replacing dead cells with new, healthy neurons, using transplantation. Researchers at Lund University in Sweden have taken a step in that direction by showing that some neurons transplanted into the brains of stroke-injured rats were incorporated and responded correctly when the rat's muzzle and paws were touched.
The study, published in the prestigious journal Brain, used . These were re-programmed to the stem cell stage and then matured into the type of neurons normally found in the cerebral cortex.
A couple of years ago, the research team at the Stem Cell Centre in Lund had already proven that transplanting this type of cells to the enabled stroke-injured rats to move better. At the time, however, it was unclear whether the host brain really formed functioning connections with the transplanted . Now the new study has proven that this is indeed the case.
The research team used several advanced methods in the study – electron microscopy, virus-based tracing techniques, registration of activity in the and optogenetics. The results show that various parts of the host brain form normal, functioning connections with the transplanted neurons and that the latter change their activity when the animal's muzzle and paws are touched.
"This is the first time anyone has been able to show such a result. That some of the new nerve cells receive signals from the host brain in a normal way indicates that they have been incorporated into the stroke-injured rat's brain. In it, they have been able to replace some of the dead nerve cells," says the professor at the Stem Cell Centre, Zaal Kokaia.
Now, a stroke-injured laboratory animal is not the same as a stroke patient. But professor and consultant physician Olle Lindvall, who is also part of the research team, still sees the team's study as an important first step. It constitutes what is known as proof of concept, showing that it is possible to replace dead neurons with new, healthy cells through transplantation after a stroke.
"This is basic research, and it is not possible to say when we will be ready to start experiments on patients. But the objective is clear: to develop a treatment method which can repair the stroke-injured brain. Currently, there is no effective treatment which can restore function in a stroke patient once the first hours following a stroke have passed," says Zaal Kokaia.

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